Dave's Blog

Thought Of The Day – AMPK, Pulmonary Vasculature & RV

Today’s thought stems from a quote I found reading Metabolic Regulation: A Human Perspective by Keith N. Frayn. This is one of my new favorite books… Quote: “AMPK senses energy status of the cell: when there is a drain on ATP, AMP rises and the AMPK is activated, leading in turn to inhibition of ATP utilizing pathways (particularly biosynthetic pathways) and activation of ATP-generating pathways (glucose uptake, glycolysis, fatty acid oxidation).” Thought: AMPK (5′ AMP-activated protein kinase) activation in some form, either via dietary means, or as a drug target, would seem to be a good idea for the pulmonary vasculature as

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SearchingPHorACure.com, Now Live!

Welcome! This blog is a personal project of mine… one with the sole aim of finding a cure for Pulmonary Hypertension, and Cardiopulmonary diseases at large. By writing about the science of cardiopulmonary vascular diseases, the latest news in the field, new theories and ideas, as well as musings about nutrition and health/lifestyle choices, it is my hope that this website and its content may somehow help in fostering creativity, innovation, knowledge, and awareness in the Pulmonary Hypertension community, and ultimately help bring the prospect of a cure one step closer… This blog is both technical and non-technical and is written for audiences

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Fear of Creative Destruction is not new, but why does it persist?

Creative destruction is a term coined by the economist Joseph Schumpeter to indicate that, while temporarily painful to those affected, technological innovation that causes job losses in certain sectors of industries ultimately creates wealth and prosperity for everyone (including those affected). Cars displaced horse carriage manufacturers… a significant advantage for everyone and the modern world, we can all agree. This doesn’t mean there are no horse carriage manufacturers, just a few niche ones left, which are actually profitable. There doesn’t need to be a thousand horse carriage manufacturers anymore… it just doesn’t make any economic sense. Who today can deny that

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The Implications of Dodd-Frank

This weeks EconTalk episode highlights some interesting facts about regulation and the current regulatory landscape. The excerpt below is by Lee Ohanian, professor of economics at UCLA and senior fellow at the Hoover Institution, and pertains to the Dodd-Frank legislation: “Now, some of the regulations we see today, in my view, are perhaps even more inefficient than ones we’ve seen in previous years. There’s Dodd-Frank in the financial sector, which is unique piece of legislation. It doesn’t provide rules directed at individual’s [or] organizations, which is the intent of the legislation. Rather it is a directive for bureaucrats to create

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McKinsey on Disciplined Innovation

McKinsey Insights has a great article on the art of Disciplined Innovation. A cogent excerpt from the article below highlights the importance of simple constraints in fostering successful innovation. Simple rules/constraints can apply to organizations undergoing small iterative innovative processes, as well as large scale disruptive innovation.   “How, then, can organizations embrace a more disciplined approach to innovation? One productive approach is to apply a few simple rules to key steps in the innovation process. Simple rules add just enough structure to help organizations avoid the stifling bureaucracy of too many rules and the chaos of none at all.

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On Walking

“You’ve got brains in your head and feet in your shoes. You can steer yourself any direction you choose.” –Dr. Seuss Every person who is worth imitating has at least one of two things in common… they walk and/or and they meditate. There are absolutely some other qualities, which are (and should be) “imitate-able”, but these are two that are relatively simple and quickly adaptable. At first glance, walking seems like something that is just a waste of time. Of all the forms of physical exercise, it would appear that walking is the one with the least amount of visible

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My 2015 New Years Resolutions

Below are some of my resolutions for the upcoming year. I’m pretty excited to close out 2014, but at the same time, the year flew by too quickly… Regardless, I’m eager to start another, with a fresh perspective, and I’m going to really try to make a concerted effort to be mindful and present in each moment. Time just flies by too fast. I hope everyone has an amazing, positive, and fulfilling year.   2015 Motto Think big, ask better questions & get more specific in my goals (& in my thinking in general), push my comfort zone, be mindful

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Living Paleo: 2 Years and Counting…

I’ve been on The Paleo Diet for 2 years now and I’ve never felt better in my life. I’ve noticed significant improvements in my overall mood, energy levels, and mental focus. Aside from that, I’m in the best shape I’ve ever been in. What’s more is that these changes took place relatively soon after I started eating Paleo, and while they occurred quickly, they’ve also been developing over time. For those who don’t know, The Paleo Diet (in short) advocates consuming protein, vegetables, fruit, and healthy fats, and avoiding carbs and sugars (bread, pasta, flour, rice, candy, etc.). The reasoning

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Michelangelo And You

Michelangelo said his talent was in revealing. He would see a block of stone, determine what it was, and chip away to reveal it. You are a block of stone. In life, you chip away to sculpt your true, idealized self. This self as an end isn’t achievable, and it shouldn’t be since nothing is perfect. But as life progresses, you chip away towards this vision. You can’t help but do it. You feel compelled to. As you’re chipping away though, every time you aren’t your true self, every time you aren’t in control of your outlook, every time you

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The Benefits & Drawbacks Of Exhaustive Reading

The benefits of going into a book completely, of being completely absorbed by it: …you absorb everything in the authors mind, their way of life, patterns of thinking (how they arrive to certain conclusions, their mental shortcuts, etc.) character, outlook, disposition, mental modes/frameworks… That is to say, reading in this way gives you a new lens with which to view the world. It can help you to open your eyes and experience new/alternate patterns of thinking that might not have been possible before. This is obviously a good thing, and mainly for some of the following reasons: 1) you gain

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