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“Regulation Of Pulmonary Macrophage Function In Health And Disease” – A Synopsis

Below is a video and synopsis of the talk “Regulation Of Pulmonary Macrophage Function In Health And Disease” by Dr. Bruce Trapnell at the Vera Moulton Wall Center for Pulmonary Vascular Disease: Summary GM-CSF is important for macrophages to clear adenovirus transfections Normally, an adenovirus exits the endosome and is targets the nucleus of the cell and dumps its DNA into the nucleus In cells, GM-CSF redirects adenovirus to lysosomes via PU.1 GM-CSF receptor has pleiotropic effects on macrophages: low concentrations of GM-CSF leads to signaling that induces differentiation and survival of macrophages, and at higher concentrations, that pathway is

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